Yang Lab

Publications

V.A. Villareal, D. Fu, D.A. Costello, X.S. Xie, and P.L. Yang. (2016). Hepatitis C Virus Selectively Alters the Intracellular Localization of Desmosterol. ACS Chem Biol, Publication Date (Web) April 29, 2016. DOI: 10.1021/acschembio.6b00324.

M.J. Clark, C. Midituru, A.G. Schmidt, X. Zhu, J.D. Pitts, J. Wang, S. Potisopon, J. Zhang, A. Wojciechowski, J.J.-H Chu, N.S. Gray, and P.L. Yang. (2016) GNF-2 Inhibits Dengue Virus by Targeting Abl Kinases and the Viral E Protein. Cell Chem Biol, 23(4):443-52.

M. Carocci and P.L. Yang. (2016) Lactimidomycin is a broad-spectrum inhibitor of dengue and other RNA viruses. Antiviral Research. 128:57-62.

V.A. Villareal, M.A. Rodgers, D.A. Costello, P.L. Yang. (2015) Targeting host lipid metabolism to inhibit dengue and hepatitis C viruses. Antiviral Research 124:110-21. doi: 10.1016/j.antiviral.2015.10.013.

F. Inci, C. Filippini, M. Baday, M.O. Ozen, S. Calamak, N.G. Durmus, S.Q. Wang, E. Hanhauser, K.S. Hobbs, F. Juillard, P.P. Kuang, M.L. Vetter, M. Carocci, H.S. Yamamoto, Y. Takagi, U.H. Yildiz, D. Akin, D.R. Wesemann, A. Singhal, P.L. Yang, M.L. Nibert, R. N. Fichorova, D. T.-Y. Lau, T. J. Henrich, K. M. Kaye, S.C. Schacter, D. Kuritzkes, L.M. Steinmetz, S.S. Gambhir, R.W. Davis, and U. Demirci. (2015) Multitarget, quantitative nanoplasmonic electrical-field enhanced resonating device for diagnostics. Proc Natl Acad Sci USA, 112(32):E4354-63.

Carocci, M., Hinshaw, S.M., Rodgers, M.A., Villareal, V.A., Burri, D.J., Pilankatta, R., Maharaj, N.P., Gack, M.U., Stavale, E.J., Warfield, K.L., Yang, P.L. (2015) The bioactive lipid 4-hydroxyphenyl retinamide inhibits flavivirus replication. Antimicrob Agents Chemother. 2015 Jan;59(1):85-95. doi: 10.1128/AAC.04177-14. Epub 2014 Oct 13. PMID: 25313218.

Vetter, M.L., Zhang, Z., Liu, S., Wang, J., Cho, H., Zhang, J., Zhang, W., Gray, N.S., Yang, P.L. (2014) Fluorescent visualization of Src by using dasatinib-BODIPY. Chembiochem. 2014 Jun 16;15(9):1317-24. doi: 10.1002/cbic.201402010. Epub 2014 May 14. PMID: 24828915.

de Wispelaere, M., LaCroix, A.J., Yang, P.L. (2013) The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via Fyn kinase. J Virol. 2013 Jul;87(13):7367-81. doi: 10.1128/JVI.00632-13. Epub 2013 Apr 24. PMID: 23616652.

Vetter, M.L., Rodgers, M.A., Patricelli, M.P., Yang, P.L. (2012) Chemoproteomic profiling identifies changes in DNA-PK as markers of early dengue virus infection. ACS Chem Biol. 2012 Dec 21;7(12):2019-26. doi: 10.1021/cb300420z. Epub 2012 Oct 2. PMID: 22999307.

Zhang, Z., Kwiatkowski, N., Zeng, H., Lim, S.M., Gray, N.S., Zhang, W., and Yang, P.L. (2012) Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy. Molecular BioSystems 2012 Oct;8(10):2523-6. doi: 10.1039/c2mb25099c. Highlighted as a HOT Article. PMCID 22673640.

de Wispelaere, M. and Yang, P.L. (2012) Mutagenesis of the domain I - domain III linker in the Dengue Virus envelope protein impairs viral particle assembly. Journal of Virology, 86(13):7072-7083. PMCID: PMC3416339.

Rodgers, M.A., Villareal, V.A., Schaefer, E.A., Peng, L.F., Corey, K.E., Chung, R.T., and Yang, P.L. (2012) Lipid metabolite profiling identifies desmosterol metabolism as a new antiviral target for hepatitis C virus. Journal of the American Chemical Society, 134(16):6896-6899. NIHMS370147, PMCID: PMC3375380.

Schmidt, A., Lee, K., Yang, P.L., and Harrison, S.L. (2012) Small molecules of dengue virus entry. PLoS Pathogens 8(4): e1002627. PMCID: PMC3320583.

Yang, P.L., Gao, M., Lin, K., Liu, Q., Villareal V.A. (2011) Anti-HCV drugs in the pipeline. Current Opinion in Virology, 1(6):607-616.

Schmidt, A., Yang, P.L., and Harrison, S.L. (2010) Peptide inhibitors of flavivirus entry derived from the E-protein stem. Journal of Virology, 84(24):12549-54. PMCID: PMC3004314.

Schmidt, A., Yang, P.L., and Harrison, S.L. (2010) Peptide inhibitors of dengue-virus entry target a late-stage fusion intermediate. PLOS Pathogens 6(4):e1000851.doi:10.1371/journal.ppat.1000851. PMCID: PMC2851732.

Yang, P.L.*, Althage, A., Chung, J.S., Maier, H., Wieland, S., Isogawa, M., and Chisari, F.V. (2010) Immune effectors required for hepatitis B virus clearance. Proc Natl Acad Sci USA, 107(2), 798-802. * corresponding author. PMCID: PMC2818933.

Sessions, O.M., Barrows, N.J., Souza-Neto, J.A., Robinson, T.J., Hershey, C.L., Rodgers, M.A., Ramirez, J.L., Dimopoulos, G., Yang, P.L., Pearson, J.L., and Garcia-Blanco, M.A. (2009). Discovery of insect and human dengue virus host factors. Nature, 458(7241), 1047-1050. NIHMSID: NIHMS103021.

Rodgers, M.A., Saghatelian, A., and Yang, P.L. (2009). Identification of an overabundant cholesterol precursor in hepatitis B virus replicating cells by untargeted lipid metabolite profiling. Journal of the American Chemical Society, 131(14), 5030-5031.

Zhang, J., Yang, P.L., and Gray, N.S. (2009). Targeting cancer with small molecule kinase inhibitors. Nat Rev Cancer, 9(1), 28-39.

Hwang, Y.C., Chu, J.J.H., Yang, P.L., Chen, W., and Yates, M.V. (2008). Rapid identification of inhibitors that interfere with poliovirus replication using a cell-based assay. Antiviral Research 77(3), 232236.

Chu, J.J.-H., Yang, P.L.. (2007). c-Src protein kinase inhibitors block assembly and maturation of dengue virus. Proc Natl Acad Sci USA, 104(9), 3520-3525.

P.L. Yang, A. Althage, J.S. Chung, F.V. Chisari. (2002) Hydrodynamic transfection: a new model for acute hepatitis B virus infection. Proc Natl Acad Sci USA. 99(21):13825-13830.

J. Gildersleeve, J. Janes, H. Ulrich, P. Yang, C. Barbos, P.G. Schultz. (2002) Development of a genetic selection for catalytic antibodies. Bioorg Med Chem Lett 12(12): 1691-1694.

J. Yun, E.C. Mundorff, P.L. Yang, K.U. Wendt, D. Hanway, R.C. Stevens, P.G. Schultz. (2001) A comparative analysis of the immunological evolution of antibody 28B4. Biochemistry 40(36):10764-73.

P.L. Yang and P.G. Schultz. (1999) Mutational analysis of the affinity maturation of antibody 48G7. (1999). Journal of Molecular Biology 294(5):1191-201.

P.A. Patten, N.S. Gray, P.L. Yang, C.B. Marks, G. J. Wedemayer, J.J. Boniface, R.C. Stevens, P.G. Schultz. (1996). The immunological evolution of catalysis. Science (Washington D C) 271 (5252), 1086-1091.

H.D. Ulrich, P.A. Patten, P.L. Yang, F.E. Romesberg, P.G. Schultz. (1995). Expression studies of catalytic antibodies. Proceedings of the National Academy of Sciences of the United States of America 92 (25), 11907-11911.