Interrogation of host-dengue virus interactions with small molecules and RNA interference

We are interested in identifying the biochemical pathways and potential pharmacological intervention points associated with dengue virus infection of the host cell. In particular, we are using small molecules and RNA interference to discover these interactions at both the molecular and pathway levels. The goal of our research is to increase our basic understanding of dengue virus’s interactions with its host cell and to contribute, ultimately, to the development of therapies for the treatment of dengue virus infection.

1. Using small molecule kinase inhibitors to identify cellular kinases important for dengue virus infection
2. Using RNA interference to identify host factors required for dengue virus infection