Yang Lab

Publications

Tallorin L, Villareal VA, Hsia CY, Rodgers MA, Burri DJ, Pfeil MP, Llopis PM, Lindenbach BD, Yang PL. Hepatitis C virus NS3-4A protease regulates the lipid environment for RNA replication by cleaving host enzyme 24-dehydrocholesterol reductase. J Biol Chem. 2020 Aug 28;295(35):12426-12436. doi: 10.1074/jbc.RA120.013455. Epub 2020 Jul 8. PubMed PMID: 32641492; PubMed Central PMCID: PMC7458815.

de Wispelaere M, Carocci M, Burri DJ, Neidermyer WJ Jr, Olson CM, Roggenbach I, Liang Y, Wang J, Whelan SPJ, Gray NS, Yang PL. A broad-spectrum antiviral molecule, QL47, selectively inhibits eukaryotic translation. J Biol Chem. 2020 Feb 7;295(6):1694-1703. doi: 10.1074/jbc.RA119.011132. Epub 2019 Dec 30. PubMed PMID: 31914414; PubMed Central PMCID: PMC7008383.

de Wispelaere M, Du G, Donovan KA, Zhang T, Eleuteri NA, Yuan JC, Kalabathula J, Nowak RP, Fischer ES, Gray NS, Yang PL. Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations. Nat Commun. 2019 Aug 1;10(1):3468. doi: 10.1038/s41467-019-11429-w. PubMed PMID: 31371704; PubMed Central PMCID: PMC6672008.

Pitts J, Hsia CY, Lian W, Wang J, Pfeil MP, Kwiatkowski N, Li Z, Jang J, Gray NS, Yang PL. Identification of small molecule inhibitors targeting the Zika virus envelope protein. Antiviral Res. 2019 Apr;164:147-153. doi: 10.1016/j.antiviral.2019.02.008. Epub 2019 Feb 13. PubMed PMID: 30771406; PubMed Central PMCID: PMC6675404.

Li PC, Jang J, Hsia CY, Groomes PV, Lian W, de Wispelaere M, Pitts JD, Wang J, Kwiatkowski N, Gray NS, Yang PL. Small Molecules Targeting the Flavivirus E Protein with Broad-Spectrum Activity and Antiviral Efficacy in Vivo. ACS Infect Dis. 2019 Mar 8;5(3):460-472. doi: 10.1021/acsinfecdis.8b00322. Epub 2019 Jan 14. PubMed PMID: 30608640; PubMed Central PMCID: PMC6548335.

Schmidt AG, Lee K, Yang PL, Harrison SC. Correction: Small-Molecule Inhibitors of Dengue-Virus Entry. PLoS Pathog. 2019 Jan;15(1):e1007553. doi: 10.1371/journal.ppat.1007553. eCollection 2019 Jan. PubMed PMID: 30703168; PubMed Central PMCID: PMC6355023.

Kaushansky A, Hedstrom L, Goldman A, Singh J, Yang PL, Rathod PK, Cynamon M, Wodarz D, Mahadevan D, Tomaras A, Navia MA, Schiffer CA. A call to arms: Unifying the fight against resistance. Sci Signal. 2018 Oct 23;11(553). doi: 10.1126/scisignal.aav0442. PubMed PMID: 30352947; PubMed Central PMCID: PMC6464114.

Lian W, Jang J, Potisopon S, Li PC, Rahmeh A, Wang J, Kwiatkowski NP, Gray NS, Yang PL. Discovery of Immunologically Inspired Small Molecules That Target the Viral Envelope Protein. ACS Infect Dis. 2018 Sep 14;4(9):1395-1406. doi: 10.1021/acsinfecdis.8b00127. Epub 2018 Aug 29. PubMed PMID: 30027735; PubMed Central PMCID: PMC6392429.

de Wispelaere M, Lian W, Potisopon S, Li PC, Jang J, Ficarro SB, Clark MJ, Zhu X, Kaplan JB, Pitts JD, Wales TE, Wang J, Engen JR, Marto JA, Gray NS, Yang PL. Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein. Cell Chem Biol. 2018 Aug 16;25(8):1006-1016.e8. doi: 10.1016/j.chembiol.2018.05.011. Epub 2018 Jun 21. PubMed PMID: 29937406; PubMed Central PMCID: PMC6097893.

Pitts JD, Li PC, de Wispelaere M, Yang PL. Antiviral activity of N-(4-hydroxyphenyl) retinamide (4-HPR) against Zika virus. Antiviral Res. 2017 Nov;147:124-130. doi: 10.1016/j.antiviral.2017.10.014. Epub 2017 Oct 16. PubMed PMID: 29051080; PubMed Central PMCID: PMC5703041.

Liang Y, de Wispelaere M, Carocci M, Liu Q, Wang J, Yang PL, Gray NS. Structure-Activity Relationship Study of QL47: A Broad-Spectrum Antiviral Agent. ACS Med Chem Lett. 2017 Mar 9;8(3):344-349. doi: 10.1021/acsmedchemlett.7b00008. eCollection 2017 Mar 9. PubMed PMID: 28337328; PubMed Central PMCID: PMC5346993.

de Wispelaere M, Carocci M, Liang Y, Liu Q, Sun E, Vetter ML, Wang J, Gray NS, Yang PL. Discovery of host-targeted covalent inhibitors of dengue virus. Antiviral Res. 2017 Mar;139:171-179. doi: 10.1016/j.antiviral.2016.12.017. Epub 2016 Dec 26. PubMed PMID: 28034743; PubMed Central PMCID: PMC5373925.

Costello DA, Villareal VA, Yang PL. Desmosterol Increases Lipid Bilayer Fluidity during Hepatitis C Virus Infection. ACS Infect Dis. 2016 Nov 11;2(11):852-862. doi: 10.1021/acsinfecdis.6b00086. Epub 2016 Aug 25. PubMed PMID: 27933788; PubMed Central PMCID: PMC5161114.

V.A. Villareal, D. Fu, D.A. Costello, X.S. Xie, and P.L. Yang. (2016). Hepatitis C Virus Selectively Alters the Intracellular Localization of Desmosterol. ACS Chem Biol, Publication Date (Web) April 29, 2016. DOI: 10.1021/acschembio.6b00324.

M.J. Clark, C. Midituru, A.G. Schmidt, X. Zhu, J.D. Pitts, J. Wang, S. Potisopon, J. Zhang, A. Wojciechowski, J.J.-H Chu, N.S. Gray, and P.L. Yang. (2016) GNF-2 Inhibits Dengue Virus by Targeting Abl Kinases and the Viral E Protein. Cell Chem Biol, 23(4):443-52.

M. Carocci and P.L. Yang. (2016) Lactimidomycin is a broad-spectrum inhibitor of dengue and other RNA viruses. Antiviral Research. 128:57-62.

V.A. Villareal, M.A. Rodgers, D.A. Costello, P.L. Yang. (2015) Targeting host lipid metabolism to inhibit dengue and hepatitis C viruses. Antiviral Research 124:110-21. doi: 10.1016/j.antiviral.2015.10.013.

F. Inci, C. Filippini, M. Baday, M.O. Ozen, S. Calamak, N.G. Durmus, S.Q. Wang, E. Hanhauser, K.S. Hobbs, F. Juillard, P.P. Kuang, M.L. Vetter, M. Carocci, H.S. Yamamoto, Y. Takagi, U.H. Yildiz, D. Akin, D.R. Wesemann, A. Singhal, P.L. Yang, M.L. Nibert, R. N. Fichorova, D. T.-Y. Lau, T. J. Henrich, K. M. Kaye, S.C. Schacter, D. Kuritzkes, L.M. Steinmetz, S.S. Gambhir, R.W. Davis, and U. Demirci. (2015) Multitarget, quantitative nanoplasmonic electrical-field enhanced resonating device for diagnostics. Proc Natl Acad Sci USA, 112(32):E4354-63.

Carocci, M., Hinshaw, S.M., Rodgers, M.A., Villareal, V.A., Burri, D.J., Pilankatta, R., Maharaj, N.P., Gack, M.U., Stavale, E.J., Warfield, K.L., Yang, P.L. (2015) The bioactive lipid 4-hydroxyphenyl retinamide inhibits flavivirus replication. Antimicrob Agents Chemother. 2015 Jan;59(1):85-95. doi: 10.1128/AAC.04177-14. Epub 2014 Oct 13. PMID: 25313218.

Vetter, M.L., Zhang, Z., Liu, S., Wang, J., Cho, H., Zhang, J., Zhang, W., Gray, N.S., Yang, P.L. (2014) Fluorescent visualization of Src by using dasatinib-BODIPY. Chembiochem. 2014 Jun 16;15(9):1317-24. doi: 10.1002/cbic.201402010. Epub 2014 May 14. PMID: 24828915.

de Wispelaere, M., LaCroix, A.J., Yang, P.L. (2013) The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via Fyn kinase. J Virol. 2013 Jul;87(13):7367-81. doi: 10.1128/JVI.00632-13. Epub 2013 Apr 24. PMID: 23616652.

Vetter, M.L., Rodgers, M.A., Patricelli, M.P., Yang, P.L. (2012) Chemoproteomic profiling identifies changes in DNA-PK as markers of early dengue virus infection. ACS Chem Biol. 2012 Dec 21;7(12):2019-26. doi: 10.1021/cb300420z. Epub 2012 Oct 2. PMID: 22999307.

Zhang, Z., Kwiatkowski, N., Zeng, H., Lim, S.M., Gray, N.S., Zhang, W., and Yang, P.L. (2012) Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy. Molecular BioSystems 2012 Oct;8(10):2523-6. doi: 10.1039/c2mb25099c. Highlighted as a HOT Article. PMCID 22673640.

de Wispelaere, M. and Yang, P.L. (2012) Mutagenesis of the domain I - domain III linker in the Dengue Virus envelope protein impairs viral particle assembly. Journal of Virology, 86(13):7072-7083. PMCID: PMC3416339.

Rodgers, M.A., Villareal, V.A., Schaefer, E.A., Peng, L.F., Corey, K.E., Chung, R.T., and Yang, P.L. (2012) Lipid metabolite profiling identifies desmosterol metabolism as a new antiviral target for hepatitis C virus. Journal of the American Chemical Society, 134(16):6896-6899. NIHMS370147, PMCID: PMC3375380.

Schmidt, A., Lee, K., Yang, P.L., and Harrison, S.L. (2012) Small molecules of dengue virus entry. PLoS Pathogens 8(4): e1002627. PMCID: PMC3320583.

Yang, P.L., Gao, M., Lin, K., Liu, Q., Villareal V.A. (2011) Anti-HCV drugs in the pipeline. Current Opinion in Virology, 1(6):607-616.

Schmidt, A., Yang, P.L., and Harrison, S.L. (2010) Peptide inhibitors of flavivirus entry derived from the E-protein stem. Journal of Virology, 84(24):12549-54. PMCID: PMC3004314.

Schmidt, A., Yang, P.L., and Harrison, S.L. (2010) Peptide inhibitors of dengue-virus entry target a late-stage fusion intermediate. PLOS Pathogens 6(4):e1000851.doi:10.1371/journal.ppat.1000851. PMCID: PMC2851732.

Yang, P.L.*, Althage, A., Chung, J.S., Maier, H., Wieland, S., Isogawa, M., and Chisari, F.V. (2010) Immune effectors required for hepatitis B virus clearance. Proc Natl Acad Sci USA, 107(2), 798-802. * corresponding author. PMCID: PMC2818933.

Sessions, O.M., Barrows, N.J., Souza-Neto, J.A., Robinson, T.J., Hershey, C.L., Rodgers, M.A., Ramirez, J.L., Dimopoulos, G., Yang, P.L., Pearson, J.L., and Garcia-Blanco, M.A. (2009). Discovery of insect and human dengue virus host factors. Nature, 458(7241), 1047-1050. NIHMSID: NIHMS103021.

Rodgers, M.A., Saghatelian, A., and Yang, P.L. (2009). Identification of an overabundant cholesterol precursor in hepatitis B virus replicating cells by untargeted lipid metabolite profiling. Journal of the American Chemical Society, 131(14), 5030-5031.

Zhang, J., Yang, P.L., and Gray, N.S. (2009). Targeting cancer with small molecule kinase inhibitors. Nat Rev Cancer, 9(1), 28-39.

Hwang, Y.C., Chu, J.J.H., Yang, P.L., Chen, W., and Yates, M.V. (2008). Rapid identification of inhibitors that interfere with poliovirus replication using a cell-based assay. Antiviral Research 77(3), 232236.

Chu, J.J.-H., Yang, P.L.. (2007). c-Src protein kinase inhibitors block assembly and maturation of dengue virus. Proc Natl Acad Sci USA, 104(9), 3520-3525.

P.L. Yang, A. Althage, J.S. Chung, F.V. Chisari. (2002) Hydrodynamic transfection: a new model for acute hepatitis B virus infection. Proc Natl Acad Sci USA. 99(21):13825-13830.

J. Gildersleeve, J. Janes, H. Ulrich, P. Yang, C. Barbos, P.G. Schultz. (2002) Development of a genetic selection for catalytic antibodies. Bioorg Med Chem Lett 12(12): 1691-1694.

J. Yun, E.C. Mundorff, P.L. Yang, K.U. Wendt, D. Hanway, R.C. Stevens, P.G. Schultz. (2001) A comparative analysis of the immunological evolution of antibody 28B4. Biochemistry 40(36):10764-73.

P.L. Yang and P.G. Schultz. (1999) Mutational analysis of the affinity maturation of antibody 48G7. (1999). Journal of Molecular Biology 294(5):1191-201.

P.A. Patten, N.S. Gray, P.L. Yang, C.B. Marks, G. J. Wedemayer, J.J. Boniface, R.C. Stevens, P.G. Schultz. (1996). The immunological evolution of catalysis. Science (Washington D C) 271 (5252), 1086-1091.

H.D. Ulrich, P.A. Patten, P.L. Yang, F.E. Romesberg, P.G. Schultz. (1995). Expression studies of catalytic antibodies. Proceedings of the National Academy of Sciences of the United States of America 92 (25), 11907-11911.